About Pure One	Dr Doughman, PhD Suggested Recommendation: 4 Concentrated Omega-3 Capsules Daily (Four Pure One Capsules Give 1200mg DHA + 40 mg EPA)
Buy 5 get 1 FREE	ABOUT DR DOUGHMAN, PHD

Why Omega-3 Improves Cardiovascular Heart Health

Pure One™ is the  first scientifically Optimized Omega 3 available.  It has the dose of DHA and EPA at a ratio that most closely matches your body's needs.

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Clinical Omega-3 Benefits in Coronary Heart Disease:

In the 1970’s researchers noted that Eskimo populations consumed extremely high levels of fat from fish and blubber, but this contradicted hypotheses of coronary heart disease at the time because the indigenous populations had no signs of cardiovascular disease. High levels of EPA/DHA are thought to be the protective complement. Recently, DART and GISSIP clinical studies of fish oil supplementation revealed 15-45% reduction in mortality in ‘at risk’ patients for coronary heart disease. Reductions in sudden death were particularly significant.

One small fish oil supplementation study in Norway did not show significant improvements, probably because of habitual incorporation of cold water fish as a regular part of the diet. The latter result can be explained by assuming that omega-3 status was optimum to begin with, suggesting that with full EPA/DHA essentiality in the background this meant coronary heart diseases in Norway were likely due to additional factors such as obesity or genetic factors that played dominant roles in participating subjects. However, most of the risks of coronary heart disease globally are associated with diet.  A high incidence of diet induced coronary heart disease occurs in many countries, including India. 

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Arrhythmias:

The benefits of omega-3s were originally thought to be due to their antithrombotic effects, but recent evidence has indicated that the predominant effect may be antiarrhythmic. Omega-3 supplementation decreased heart rate variability in patients after myocardial infarction, which correlated with a lower risk of mortality and malignant arrhythmia. In fact, direct addition of EPA/DHA into media with cultured cardiomyocytes prevents or terminates pharmacologically induced or electrically clamped arrhythmias. The modulation of plasma membrane permeability and the stabilization of ion channel functions are suggested to be acute protective properties of EPA/DHA on heart muscle cells.

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Atherosclerosis and Inflammation:

Omega 3 fatty acids may also influence the atherosclerotic process. Again, in patients with coronary heart disease EPA/DHA supplementation versus placebo for two years resulted in modest improvements in atherosclerosis as assessed by angiography. An important recent study of patients awaiting carotid artery surgery randomized cohorts to fish oil capsules, sunflower oil capsules, or controls up until surgery and then assessed morphology of the plaque. Omega 3 fatty acids incorporated into atherosclerotic plaques in the fish oil group, and these plaques were more likely to have reduced mass with less inflammatory infiltrate and increases in thickness of fibrous caps from protective responses. These features imply a plaque that is less vulnerable to rupture and indicates EPA/DHA may help to establish plaque stability. Additional improvements in overall endothelial function and decreases in pro-inflammatory signals have also been noted. The fundamental cellular processes activated or suppressed by omega-3 supplementation and their potential impact on coronary heart disease are active areas of research.